Journal article
Increased paternal corticosterone exposure influences offspring behaviour and expression of urinary pheromones
Lucas B Hoffmann, Evangeline A McVicar, Rebekah V Harris, Coralina Collar-Fernandez, Michael B Clark, Anthony J Hannan, Terence Y Pang
BMC Biology | BMC | Published : 2023
Abstract
Background: Studies have shown that paternal stress prior to conception can influence the innate behaviours of their offspring. The evolutionary impacts of such intergenerational effects are therefore of considerable interest. Our group previously showed in a model of daily stress that glucocorticoid treatment of adult male mouse breeders prior to conception leads to increased anxiety-related behaviours in male offspring. Here, we aimed to understand the transgenerational effects of paternal stress exposure on the social behaviour of progeny and its potential influence on reproductive success. Results: We assessed social parameters including social reward, male attractiveness and social domi..
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Funding Acknowledgements
We thank Brett Purcell for his assistance with behavioural data collection, Craig Thomson and Helen Huckle for providing beddings for the Social Conditioned-Place Preference, Shanshan Li for assistance with MUP protein analysis, AGRF for sequencing the offspring mRNA, the LIEF HPC-GPGPU Facility for long-read sequencing the sperm samples, and Galaxy Australia and Spartan HPC at the University of Melbourne for providing the platform for bioinformatic analyses. This research was supported by The University of Melbourne's Research Computing Services and the Petascale Campus Initiative. This research was undertaken using the LIEF HPC-GPGPU Facility hosted at the University of Melbourne. This Facility was established with the assistance of LIEF Grant LE170100200.